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Of the 121 patients who received lung transplants during the enrollment period, 58 were randomly assigned to a study group and 56 received at least one dose of study medication (inhaled cyclosporine, 26; placebo aerosol, 30) ( Figure 1 Study Enrollment and Inclusion in the Intention-to-Treat and Survival Analyses.

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Nonaerosol covariates that were tested in multivariate analyses included CMV-mismatch status, HLA-mismatch status, the age and sex of the recipient, the age and sex of the donor, smoking history of the recipient, diagnosis before transplantation, type of transplantation (single or double), and ischemic time.

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Cyclosporine is a potent immunosuppressive agent which in animals prolongs survival of allogeneic transplants involving skin, heart, kidney, pancreas, bone marrow, small intestine, and lung.

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Four patients with a known previous diagnosis of rejection (three with bronchiolitis obliterans) or pneumonia died outside our institution (three in the placebo group and one in the cyclosporine group) without postmortem verification of the cause of death.

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