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I have had Polycythemia vera for 25 years. I was started on hydroxyurea two months ago and recently developed severe petechial hemorrhaging. I was admitted to the hospital with a platelet count of 9,000. I received a six pack of platelets and over seven days (being off the medication) my platelet count had climbed to 74,000. As of Sunday, July 5th, it was at 139,000 (off the medication for ten days). I was given the medication to help prevent the POTENTIAL of developing a blood clot. I have managed my Polycythemia vera pretty well without medication for 25 years (I do take baby aspirin) and wish I had never taken this.

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Because knowledge of repeated measurements of a patient's mean corpuscular volume or fetal hemoglobin level might make the treatment assignments apparent to staff members, such measurements were made at the central laboratory.

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Selected parameters from MOS Short-Form SF-36 Health Quality of Life and the Profile of Mood States in adults with moderate-severe sickle cell anemia, treated with hydroxyurea or placebo for two years, and classified according to 2-year Hb-F response or placebo (short dashes).

People with anemia may need blood transfusions.

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My view is that untreated sickle cell disease is a worse disease for a child to have than acute leukaemia.

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Hydroxyurea gave adequate control of red cells, platelets, and spleen size.

Splenic sequestration is a life-threatening crisis, causing pooling of blood in the spleen and resulting in profound anemia, hypovolemia, cardiovascular collapse, and possible death.

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These data suggest that induction of fetal hemoglobin by hydroxyurea is an essential mechanism for its clinical benefits.

The dependent variables are: SF-36 Health Status Survey variables (as a percent scores), Mood Profile, Ladder of Life.

Hydroxyurea also known as hydroxycarbamide is a medicine that has been around for nearly 150 years.

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They were asked to rate their response to either therapy at 14 days after beginning treatment.

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Hb SS disease in California, 70 percent of patients were admitted for a crisis; the overall rate of hospitalizations for crisis was 57 admissions per 100 years of observation.

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Pain is an undeniable focal point for patients with sickle cell disease but it's not the best focus for drug development, says one of the dying breed of physicians specializing in the condition.

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Does hydroxyurea offer any benefits to the immune system?

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The results of this study underscore the need for neuropsychological assessment when abnormal flow velocities are detected by screening TCD.

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In addition, hydroxyurea use should be extended to low-resource settings such as sub-Saharan Africa, where the burden of SCA and the need for hydroxyurea is arguably the greatest.

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Long-term (more than 4 months) antimalarial therapy may result in brownish or blue-black pigmentation, especially on the shin, face and hard palate or subungually.

Although the evidence for efficacy of hydroxyurea treatment for children is not as strong, the emerging data are supportive.

Based on the mechanism of action and findings in animals, Hydrea can cause fetal harm when administered to a pregnant woman.

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The aim of the trial was to evaluate the effect of hydroxyurea in patients with symptomatic sickle cell disease over a period of 5 years and to determine whether chronic daily oral therapy could decrease the frequency of painful vaso-occlusive episodes by 50%.

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It also improved anemia and decreased the need for transfusions and hospital admissions.

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Severe gastric distress, such as nausea, vomiting, and anorexia, resulting from combined therapy may usually be controlled by temporary interruption of this drug.

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Pain relief and intravenous fluids are the initial steps.

Unfortunately, no information is available regarding the reproductive risks of HD handling with the current use of BSC's and PPE.

However, especially in non-aggressive disease (comprising the great majority of patients), at least partial improvement is usually attainable with one regimen or another, and thus the practitioner is obligated to persist with therapeutic trials until no options remain.

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Hydroxyurea reacts with hemoglobin to produce iron nitrosyl hemoglobin, nitrite, and nitrate, but these reactions do not occur fast enough to account for the observed increases in these species in patients taking hydroxyurea.

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The effect of renal impairment on the pharmacokinetics of hydroxyurea was assessed in adult patients with sickle cell disease and renal impairment.

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Recent data strongly suggest an increased risk of venous thromboembolism in subjects with sickle cell disease and to a lesser extent, sickle cell trait.

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Nonetheless, the entire SCD population may not benefit from HU alone.

The incidence of polycythemia vera in the United States is approximately 5-17 cases per 1 million population per year.

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Polycythemia is sometimes called erythrocytosis, but the terms are not synonymous because polycythemia refers to any increase in red blood cells, whereas erythrocytosis only refers to a documented increase of red cell mass.

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We performed a cross-sectional study of 404 sickle cell disease patients cared for at the Sickle Cell Center for Adults at Johns Hopkins.

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People with SCD, their family, and other caretakers should wash their hands with soap and clean water many times each day.

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