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There were no discernible differences in raloxifene plasma concentrations among these groups; however, the influence of race cannot be conclusively determined.
Surgery to remove the area of LCIS is another option for women who have an increased risk of breast cancer due to their family history of the disease.
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Denosumab is approved by the FDA for the treatment of osteoporosis in postmenopausal women at high risk of fracture.
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Both raloxifene and bisphosphonates are indicated for the prevention and treatment of postmenopausal osteoporosis, however these medications have different efficacy and safety profiles.
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Menopause is the permanent cessation of reproductive fertility occurring some time before the end of the natural lifespan.
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Macrophages from these stressed rats exhibited decreased phagocytic and fungicidal undertaking and produced decreased amounts of nitric oxide and less TNF- and IL-1 upon in vitro culture.
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Hanley DA, Cranney A, Jones G, Whiting SJ, Leslie WD, Cole DE, Atkinson SA, Josse RG, Feldman S, Kline GA, Rosen C, Guidelines Committee of the Scientific Advisory Council of Osteoporosis Canada.
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Providing adequate daily calcium and vitamin D is a safe and inexpensive way to help reduce fracture risk.
Because of heterogeneity across studies, results were not combined in a quantitative meta-analysis.
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Some rat studies have suggested that breast cancer cells which have been exposed to tamoxifene for many years may become resistant to other SERMS as well, so raloxifene should be used cautiously in women who have had 5 years of tamoxifen.
Fewer noninvasive breast cancers occurred in the tamoxifen group compared to the raloxifene hydrochloride group.
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Recommendations for the use of bone markers in monitoring antiresorptive therapy in postmenopausal women with osteoporosis are summarized below.
Raloxifene hydrochloride tablets are not indicated for the reduction in the risk of noninvasive breast cancer.
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Growth Hormone and Insulin-like Growth Factor I as Therapeutic Modalities for Age-Related Osteoporosis.
However, bone disease in hemodialysis patients is caused by factors such as bone metabolic disorder accompanying kidney disease and postmenopausal or age-related osteoporosis, as well as by renal osteodystrophy.
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Health professionals are encouraged to utilize further continuing education and other resources to continue their investigation of women's health issues.
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This Guide offers concise recommendations regarding prevention, risk assessment, diagnosis, and treatment of osteoporosis in postmenopausal women and men age 50 and older.
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