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Comparison of combined therapies in treatment of secondary failure to glyburide.
Congenital anomalies and events that were fatal, life-threatening, associated with serious disability or incapacity, required prolonged hospitalization (apart from hospitalization related to expected pregnancy events), or required a major intervention to prevent another serious outcome were classified as serious adverse events.
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Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action.
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In contrast to the increase in p-AMPK levels, p-mTOR levels was markedly suppressed by metformin and irradiation alone or combined ().
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Here, we discuss the updated understanding of the antigluconeogenic action of metformin in the liver and the implications of the discoveries of metformin targets for the treatment of diabetes mellitus and cancer.
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Key question 2: In adults aged 18 years or older with type 2 diabetes mellitus, what is the comparative effectiveness of these treatment options in terms of the following long-term clinical outcomes: all-cause mortality, cardiovascular mortality, cardiovascular and cerebrovascular morbidity (for example, myocardial infarction and stroke), retinopathy, nephropathy, and neuropathy?
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Effects of metformin in obese patients with impaired glucose tolerance.
In the case of infertile women suffering from Polycystic Ovary Syndrome (PCOS), the drug should be used after the doctor has carried out a careful analysis and synthesis of the information obtained from a detailed physical examination, history and the results of series of investigations undergone by the couple.
Adherence to the treatment regimen was assessed quarterly on the basis of pill counts and structured interviews.
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The purpose of this American College of Physicians (ACP) guideline is to address the pharmacologic management of type 2 diabetes by comparing the effectiveness and safety of currently available oral pharmacologic treatment for type 2 diabetes.
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The fixed combination of the active ingredients dapagliflozin and metformin (trade name: Xigduo) has been approved in Germany since January 2014 the treatment of type 2 diabetes in adults with who cannot maintain adequate glycemic control through exercise and diet alone.
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