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We kunnen dit zien in twee artikels die gepubliceerd werden in de eerste helft van 2005, eentje door Saravanan, en anderen publiceerden het in de februari-uitgave van het Journal of Clinical Endocrinology and Metabolism, waarin 697 patiënten met primair hypothyroidisme waren betrokken, het andere artikel kwam van Appelhof, en weer anderen publiceerden hun artikelen in de mei-uitgave van hetzelfde Journal, en waarin 141 patiënten met primair hypothyroidisme waren betrokken.

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Tegen het einde van 2003 verscheen overhaast een stel documenten in de oktober-uitgave van het Journal of Clinical Endocrinologie and Metabolism, zoals ook een redactioneel artikel van Kaplan en anderen, en een ander artikel in de decemberuitgave van het Journal of The American Medical Association, die aantoonden dat de vervanging van T3 voor een deel van de T4 in de alleen-maar-T4 behandelde hypothyroid patiënten geen gezondheidsverbetering opleverde.

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