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We kunnen dit zien in twee artikels die gepubliceerd werden in de eerste helft van 2005, eentje door Saravanan, en anderen publiceerden het in de februari-uitgave van het Journal of Clinical Endocrinology and Metabolism, waarin 697 patiënten met primair hypothyroidisme waren betrokken, het andere artikel kwam van Appelhof, en weer anderen publiceerden hun artikelen in de mei-uitgave van hetzelfde Journal, en waarin 141 patiënten met primair hypothyroidisme waren betrokken.

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